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Preventing Pain After Heart Surgery

NCT01480765 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2024-11-05

No results posted yet for this study

Summary

The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery

Conditions

  • Pain
  • Hyperalgesia
  • Chronic Illness
  • Neuropathic Pain

Interventions

DRUG

Pregabalin

150mg (2hrs) pre operatively and twice daily post operatively for 10 days, followed by dose reduction to 75mg twice daily for 2 days and finally to 50 mg twice daily for 2 days

DRUG

Ketamine infusion

0.1mg/kg/hr for 48 hours post operatively

DRUG

Placebo capsules

Single capsule (2hrs) pre operatively and twice daily post operatively for 10 days, followed by dose reduction to single capsule twice daily for 2 days and finally to single capsule twice daily for 2 days

DRUG

Placebo infusion

Normal saline placebo intravenous infusion for 48 hours

Sponsors & Collaborators

  • Barts & The London NHS Trust

    lead OTHER

Principal Investigators

  • Sibtain Anwar, MA MB FRCA · Barts and The London NHS Trust

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-12-12
Primary Completion
2013-03-07
Completion
2013-03-07

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01480765 on ClinicalTrials.gov