Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance

Summary

Previous monocentric experiences have already highlighted the role of preoperative cardiac imaging, in particular of cardiac magnetic resonance (CMR) and tomography (CT), in improving the ablation results of scar-related ventricular tachycardia (VT). A better characterization of scar obtained with high quality CMR images and post processing data with creation of maps exploring the heart in concentric layers from the endocardium to the epicardium could allow a personalized and more precise approach to this pathology.

Aim of the study - Evaluating the feasibility and possible benefit of CMR-guided ablative approach (group 1: ablation of the "anatomical" channels of heterogeneous tissue within the scar) compared to CMR-aided approach (group 2: ablation of the "electrical" conduction channels within the scar) and standard approach (group 3: ablation guided by an electro-anatomical system without the aid of CMR) in a multi-center Tuscan study.

What would add the project to what is known - The achievement of the objectives by the project would allow to propose a personalized ablation on the basis of the scar characterization and would allow a better efficacy, efficiency of the procedure and probably also a safer treatment

Conditions

• Ventricular Tachycardia
• Myocardial Fibrosis

Interventions

PROCEDURE

Group 1, CMR-guided/aided VT ablation

Ablation of the "anatomical" channels of heterogeneous tissue within the scar

PROCEDURE

Group 2, CMR-aided VT ablation

Ablation of the "electrical" conduction channels within the scar

PROCEDURE

Group 3, Electroanatomical guided ablation

Ablation guided by an electro-anatomical system without the aid of CMR

Sponsors & Collaborators

• Azienda USL Toscana Nord Ovest

  collaborator OTHER

• Azienda USL Toscana Sud Est

  collaborator OTHER_GOV

• Azienda Ospedaliera Universitaria Senese

  collaborator OTHER

• Fondazione Toscana Gabriele Monasterio

  collaborator OTHER

• Centro Medico Teknon

  collaborator OTHER

• Azienda Ospedaliero, Universitaria Pisana

  lead OTHER

Principal Investigators

• GIULIO ZUCCHELLI, MD, PhD · Azienda Ospedaliero, Universitaria Pisana

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-08-03

Primary Completion

2025-07-17

Completion

2025-07-17

Countries

• Italy

Study Locations