Prevalence of Myocardial Scars on CMR After COVID-19 Infection

Summary

The aim of this study is to assess the prevalence and arrhythmogenic role of occult myocardial scars on Cardiac Magnetic Resonance (CMR) in a population of patients with history of laboratory-proven symptomatic COVID-19 infection managed without hospitalization, as compared to a population of age- and sex-matched healthy volunteers.

Conditions

• COVID-19
• Virus Disease

Interventions

DEVICE

Contrast-enhanced CMR

Cardiac Magnetic Resonance Imaging (MRI) examinations will be performed at Day 0 visit on clinical systems 1.5 equipped with specific antennas for cardiac imaging. The imaging protocol will last approximately 50 minutes.

DIAGNOSTIC_TEST

Exercise test ECG

A treadmill exercise test with 12 lead ECG monitoring will be performed at M3 visit. Maximum expected enrollment 30 MRI+ patients and 30 healthy volunteers MRI- matched controls.

BIOLOGICAL

Blood sample

A blood sample will be taken at Day 0 visit for COVID-19 serology, hematocrit measurement, ultra-high sensitive troponin test, low grade markers of inflammation, genetic profiling. An other blood sample will be taken at M3 visit for a control COVID-19 serology for 30 healthy volunteers.

DIAGNOSTIC_TEST

Resting 12 lead ECG

A resting 12 lead ECG will be performed at Day 0 visit.

DIAGNOSTIC_TEST

24 hour Holter ECG

A 24 hour Holter ECG will be performed at M3 visit. Maximum expected enrollment 30 MRI+ patients and 30 healthy volunteers MRI- matched controls.

Sponsors & Collaborators

• Grant Agreement ERC n°715093

  collaborator UNKNOWN

• University of Bordeaux

  collaborator OTHER

• University Hospital, Bordeaux

  lead OTHER

Principal Investigators

• Hubert COCHET, MD-PhD · University Hospital, Bordeaux

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-06-13

Primary Completion

2022-04-04

Completion

2022-04-04

Countries

• France

Study Locations