Predictive Value of Geriatric Oncology Screening and Geriatric Assessment in Older Patients With Solid Cancers

Summary

A Randomized Clinical Trial examining the effects of Comprehensive Geriatric Assessment as an add on to oncologic treatment. Participants included are cancer patients found eligible for oncologic treatment, age 70 or more, and screened frail with the Geriatric 8 screening tool.

Conditions

• Frailty
• Cancer
• Age

Interventions

OTHER

Comprehensive Geriatric Assessment and follow-up

All patients will receive standardized oncological treatment according to national guidelines. For patients randomized to the intervention arm, a full Comprehensive Geriatric Assessment (CGA) and corresponding interventions on identified health issues will be performed alongside oncologic treatment. The domains are assessed using validated tests based on a Danish version of the Geriatric Core Dataset (G-CODE). The domains are cognition, mood, comorbidity, functional status, physical status, polypharmacy, nutrition, fall risc and social support. The CGA will be performed by the PhD-student (geriatric resident) or a geriatrician together with geriatric nurses at the Department of Geriatric Medicine, OUH. Nutritional status and interventions are assessed by a dietician. A physical therapist will evaluate the physical performance as part of the CGA. Follow-up on initial treatment plan is scheduled to one month after baseline CGA.

Sponsors & Collaborators

• University of Southern Denmark

  collaborator OTHER

• Danish Cancer Society

  collaborator OTHER

• Academy of Geriatric Cancer

  collaborator UNKNOWN

• Odense Patient Data Explorative Network

  collaborator OTHER

• Region of Southern Denmark

  collaborator OTHER

• Odense University Hospital

  lead OTHER

Principal Investigators

• Ann-Kristine W Giger, MD · Department of Geriatric Medicine, Odense University Hospital, Odense

• Cecilia M Lund, MD, PhD · Department of Medicine, Herlev and Gentofte University Hospital, Copenhagen

• Per Pfeiffer, MD, PhD · Department of Clinical Oncology, Odense University Hospital, Odense

• Trine L Jørgensen, MD, PhD · Department of Clinical Oncology, Odense University Hospital, Odense

• Marianne Ewertz, MD, DMSc · Institute of Clinical Research, University of Southern Denmark, Odense

• Henrik Ditzel, MD, DMSc · Department og Geriatric Medicine, Odense University Hospital, Odense

• Jesper Ryg, MD, PhD · Department of Geriatric Medicine, Odense University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-11-01

Primary Completion

2023-11-01

Completion

2024-06-01

Countries

• Denmark

Study Locations