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Internal Microstructure of Patent Foramen Ovale Related to Stroke

NCT04686253 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1200

Last updated 2025-07-22

No results posted yet for this study

Summary

This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these patients; (2) evaluate the microstructural features of asymptomatic patients with PFO and make a follow-up；(3) perform an untargeted metabolomics analysis using plasma samples from right atrium and left atrium and shunt provocative test was conducted;(4) collect the blood sample from PFO tunnel;(5) cardiac CTA was performed to evaluate the position and morphology of device.

Conditions

  • Patent Foramen Ovale

Interventions

OTHER

not appliable

not appliable

Sponsors & Collaborators

  • Beijing Anzhen Hospital

    collaborator OTHER

  • The Affiliated Hospital of Xuzhou Medical University

    collaborator OTHER

  • Tibet Autonomous Region People's Hospital

    collaborator OTHER

  • Beijing Tiantan Hospital

    collaborator OTHER

  • Xuanwu Hospital, Beijing

    collaborator OTHER

  • China National Center for Cardiovascular Diseases

    lead OTHER_GOV

Eligibility

Min Age
16 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-23
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04686253 on ClinicalTrials.gov