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Effect of Acute Physical Exercise on Memory

NCT04680494 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2020-12-23

No results posted yet for this study

Summary

An increasing amount of studies show the beneficial effect of regular exercise on cognitive and brain functions and especially in the memory domain. Yet little is known of what happens within an acute bout of exercise and whether it would also yield cognitive effects. The literature clearly shows that molecules such as brain derived neurotrophic factor (BDNF) and endocannabinoids (mainly anandamide, AEA) are heavily involved in neural plasticity mechanisms and increase when we exercise hinting at possible mechanisms underlying memory improvement after exercise.

This protocol assesses the effects of acute exercise on associative and motor sequence memory, their underlying neural activations (measured using fMRI) and blood biomarkers (BDNF and AEA). A related aim is to assess the effect of exercise intensity, therefore three exercising conditions (rest, moderate intensity and high intensity) were included. Finally, a 3-month delayed retest visit is also realized to assess effects of acute exercise on long-term memory consolidation.

Conditions

  • Acute Physical Exercise

Interventions

OTHER

moderate intensity physical exercise

OTHER

high intensity physical exercise

OTHER

rest

Sponsors & Collaborators

  • University Hospital, Geneva

    collaborator OTHER

  • University of Geneva, Switzerland

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
38 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-10-09
Primary Completion
2016-07-27
Completion
2016-07-27

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04680494 on ClinicalTrials.gov