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The Effect of Exercise on Neurorecovery Following Mild Traumatic Brain Injury

NCT02276079 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 39

Last updated 2018-12-04

No results posted yet for this study

Summary

The study is a "proof-of-principle" project to examine the safety and feasibility of implementing a 1-week aerobic exercise program in the post-acute phase after mild traumatic brain injury (mTBI). The study will define the extent to which the exercise program improves recovery from mTBI in terms of relevant functional outcomes (cognition, mood, and physical status) and biomarkers (peripheral brain-derived neurotrophic factor \[BDNF\] concentration).

Conditions

  • Brain Concussion

Interventions

BEHAVIORAL

Aerobic Exercise

Aerobic exercise will consist of riding a stationary bicycle at moderate intensity for 2 consecutive, 20-minute periods with a 5-minute break in between. Moderate intensity is defined as maintaining 65-75% of estimated maximum heart rate based on the calculation (HRmax = 208 - 0.7 × age).

BEHAVIORAL

Non-Aerobic Exercise

Non-Aerobic exercise will consist of very low-intensity movements including static stretching and toning exercises.Participants will complete 2 consecutive, 20-minute periods with a 5-minute break in between, mirroring the aerobic exercise condition. Heart rate will be monitored by research staff to ensure that it remains below 50% of estimated maximum heart rate.

Sponsors & Collaborators

  • Clinical & Translational Science Institute

    collaborator UNKNOWN

  • American Psychological Foundation

    collaborator OTHER

  • American Psychological Association (APA)

    collaborator OTHER

  • University of Florida

    lead OTHER

Principal Investigators

  • Russell M. Bauer, Ph.D. · University of Florida

  • Aliyah R. Snyder, M.S. · University of Florida

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-02-17
Primary Completion
2016-12-22
Completion
2016-12-22

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02276079 on ClinicalTrials.gov