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Host RNA Signature in Children With Cancer and Infection

NCT04669418 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 370

Last updated 2022-12-22

No results posted yet for this study

Summary

The aim is to investigate if RNA expression signature can discriminate bacterial from viral infection or non-infectious inflammation in children with cancer.

Earlier studies in immunocompetent children have shown promising results, but studies in immunocompromised children are lacking.

We aim to include 300 febrile episodes in children with cancer. The samples will be analysed by RNA sequencing. If succesfull, this method can help prevent unnecessary antibiotic treatment, reduce hospital admissions, side effects and antimicrobial resistance and improve quality of life for children during cancer treatment.

Conditions

  • Childhood Cancer
  • Infection
  • Neutropenia, Febrile

Interventions

DIAGNOSTIC_TEST

RNA expression signature

Whole transcriptome profiling using RNA sequencing

Sponsors & Collaborators

  • Børnecancerfonden

    collaborator OTHER

  • Lundbeck Foundation

    collaborator OTHER

  • Danish Cancer Society

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Lotte M. Smedegaard, M.D. · ph.d.-student

Eligibility

Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-01
Primary Completion
2021-07-31
Completion
2021-07-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04669418 on ClinicalTrials.gov