PRotEin Provision in Critical IllneSs

Summary

Rapid skeletal muscle wasting during critical illness had a detrimental impact on both short and long term outcomes following ICU admission. Increased dietary protein delivery might attenuate skeletal muscle wasting and its subsequent effects on post-ICU function.

The investigators will conduct a 935 patient, randomised controlled, quadruple blinded parallel group trial to determine whether enteral nutrition with increased protein content in mechanically ventilated, critically ill patients is able to improve functional recovery.

Conditions

• Critical Illness
• Intensive Care Unit Acquired Weakness

Interventions

DIETARY_SUPPLEMENT

PRECISe protocol EN 8g protein/100kcal

Enteral feed containing 8g protein/100kcal

DIETARY_SUPPLEMENT

PRECISe protocol EN 5g protein/100kcal

Enteral feed containing 5g protein/100kcal

Sponsors & Collaborators

• Ziekenhuis Oost-Limburg

  collaborator OTHER

• Zuyderland Medisch Centrum

  collaborator OTHER

• Gelderse Vallei Hospital

  collaborator OTHER

• Medisch Spectrum Twente

  collaborator OTHER

• Centre Hospitalier Universitaire de Liege

  collaborator OTHER

• Centre Hospitalier Régional de la Citadelle

  collaborator OTHER

• Universitair Ziekenhuis Brussel

  collaborator OTHER

• General Hospital Groeninge

  collaborator OTHER

• Catharina Ziekenhuis Eindhoven

  collaborator OTHER

• Maastricht University Medical Center

  lead OTHER

Principal Investigators

• Marcel CG van de Poll, MD, PhD · Maastricht UMC+

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-11-19

Primary Completion

2023-10-03

Completion

2023-10-03

Countries

• Belgium
• Netherlands

Study Locations