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Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest

NCT04624776 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 158

Last updated 2023-03-29

No results posted yet for this study

Summary

Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death. This study will investigate the anti-inflammatory and neuroprotective effect of early treatment with the glucocorticoid methylprednisolone measured by interleukin-6 and neuron-specific enolase levels in resuscitated comatose OHCA-patients.

Conditions

  • Out-Of-Hospital Cardiac Arrest
  • Cardiac Arrest
  • Cardiac Arrest With Successful Resuscitation
  • Post Cardiac Arrest Syndrome
  • Systemic Inflammatory Response Syndrome
  • Neurological Injury

Interventions

DRUG

Methylprednisolone

A dosis of 250 mg methylprednisolone is suspended in isotonic saline to a total volume of 4 mL prior to infusion.

DRUG

Isotonic saline

A bolus infusion of 4 mL isotonic saline (NaCl 0.9%).

Sponsors & Collaborators

  • Christian Hassager

    lead OTHER

Principal Investigators

  • Christian Hassager, MD, DMSc · Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-10
Primary Completion
2022-07-15
Completion
2023-02-28

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04624776 on ClinicalTrials.gov