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Assessing the Impact of Antimicrobial Exposure and Infection Control Measures on the Spread of VRE

NCT04624464 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 170

Last updated 2020-11-10

No results posted yet for this study

Summary

The AEGON study is a German multicenter, prospective observational study. The study consists of two parts, which are carried out at all participating study sites and include two different patient cohorts. Part 1 focuses on the collection and analysis of rectal swabs from newly admitted VREf-negative patients at high risk of nosocomial VREf acquisition. Moreover, patients included into this part of the study will undergo in-depth documentation of clinical data if an antibiotic therapy is administered. Initiated antibiotic therapies will then be assessed by an AMS board (Antimicrobial Stewardship Board). In Part 2, environmental investigations will be performed in newly occupied single rooms of previously known VREf-positive patients. In addition, rectal swabs will be collected and data on antibiotic exposure of these patients will be documented in order to correlate the VRE contamination burden of surfaces with the intestinal VREf-load and antibiotic exposure.

Conditions

  • VRE Infection
  • Antibiotic Resistant Infection

Interventions

OTHER

Rectal swabs - microbiological analysis

Microbial analyses will be performed from the rectal swabs obtained.

OTHER

Examination of patient room

Only performed for cohort 2

Sponsors & Collaborators

  • University of Freiburg

    collaborator OTHER

  • Universitätsklinikum Hamburg-Eppendorf

    collaborator OTHER

  • University Hospital Lübeck

    collaborator OTHER

  • University Hospital of Cologne

    lead OTHER

Principal Investigators

  • Jörg Janne Vehreschild, Prof. Dr. med · University Hospital of Cologne

  • Maria J.G.T. Vehreschild, Prof. Dr. med · University Hospital of Cologne

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04624464 on ClinicalTrials.gov