Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China

Summary

This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program. They were divided into experimental group and control group according to whether the treatment plan was formulated by a multidisciplinary team. Patients of experimental group is strictly in accordance with standardized multi-disciplinary treatment protocols and meet the following criteria: 1. A multi-disciplinary conference discussion; 2. Detailed preoperative evaluation based on CT, MRI, fMRI and DSA. 3. Treatment modalities meet the following treatment criteria（craniotomy, embolization and stereotactic radiosurgery）. The control group was patients who had not been treated according to a multi-disciplinary treatment protocol.

Patient baseline data, AVM angioarchitectural features, imaging DICOM data, surgical information, and follow-up information were registered. All patients were evaluated for neurofunction at baseline, 3 months, 12 months, and 3 years after treatment. Main observation endpoints: 1. Modified Rankin Scale; 2. Obliteration rate; 3. Subsequent hemorrhage; 4. Complication rate (such as morbidity rate, new-onset neurological dysfunction, and radiation-related complications). Secondary observation endpoint: improvement of clinical symptoms (epilepsy, headache, neurological dysfunction) at 3 months, 12 months, and 3 years after treatment.

Conditions

• Brain Arteriovenous Malformation

Interventions

OTHER

Multi-disciplinary assessment

1. Comprehensive evaluation by multidisciplinary experts; 2. Preoperative multi-modal imaging examination was applied to determine the angioarchitecture, functional fiber bundle, and hemodynamics.

Sponsors & Collaborators

• Beijing Neurosurgical Institute

  collaborator OTHER

• Peking University International Hospital

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• First Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• Sichuan Provincial People's Hospital

  collaborator OTHER

• The First Hospital of Jilin University

  collaborator OTHER

• Shanxi Provincial People's Hospital

  collaborator OTHER_GOV

• The Second Hospital of Shandong University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• The General Hospital of Central Theater Command

  collaborator OTHER

• The Affiliated Hospital Of Guizhou Medical University

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• Tianjin Medical University Second Hospital

  collaborator OTHER

• The First Affiliated Hospital of Shanxi Medical University

  collaborator OTHER

• Shengjing Hospital

  collaborator OTHER

• Second Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• Hainan People's Hospital

  collaborator OTHER

• The Second Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• Second Xiangya Hospital of Central South University

  collaborator OTHER

• Second Affiliated Hospital of Soochow University

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• Lanzhou University Second Hospital

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• First Affiliated Hospital of Zhejiang University

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• Jining Medical University

  collaborator OTHER

• First Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• First Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• The Affiliated Hospital of Xuzhou Medical University

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• Binzhou Medical University

  collaborator OTHER

• The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

  collaborator OTHER

• Beijing Tiantan Hospital

  lead OTHER

Principal Investigators

• Wang Shuo, MD · Beijing Tiantan Hospital

• Li Youxiang, MD · Beijing Neurosurgical Institute

• Liu Ali, MD · Beijing Neurosurgical Institute

• Zhao Yuanli, MD · Beijing Neurosurgical Institute

• Chen Xiaolin, MD · Beijing Neurosurgical Institute

Eligibility

Min Age

1 Year

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-08-01

Primary Completion

2032-04-01

Completion

2033-04-01

Countries

• China

Study Locations