Genetic Bases of COVID-19 Clinical Variability

Summary

GEN-COVID multicenter study aims to identify the genetic variants of the host genome responsible for the clinical variability of patients with COVID-19. This variability to date is only partially related to the age and comorbidities of patients. The primary objective of the study is therefore to identify genetic variants associated with the severity of the disease, while the secondary objective consists in the identification of variants associated with longitudinal disease trajectories.

This is a laboratory study that involves the conduct of genetic investigations, including whole exome sequencing and genome wide association studies, on human biological material from patients affected by COVID-19.

Clinical information useful to describe the level of disease severity will be also collected for each enrolled patient.

A total of at least 2,000 COVID-19 patients is expected to be included.

Conditions

• COVID-19

Interventions

GENETIC

Massive parallel sequencing of host genome

Massive parallel sequencing and genotyping of host genome of individuals infected with SARS-CoV-2 and showing different clinical outcomes from asymptomatic to severely affected patients in order to identify the genetic determinants of severe COVID-19 and the genetic protective factors.

Sponsors & Collaborators

• Fondazione IRCCS Policlinico San Matteo di Pavia

  collaborator OTHER

• Ospedale San Donato, Arezzo

  collaborator UNKNOWN

• Ospedale della Misericordia

  collaborator OTHER

• Azienda Ospedaliera Ospedale Maggiore di Crema

  collaborator OTHER

• University of Modena and Reggio Emilia

  collaborator OTHER

• ASST Fatebenefratelli Sacco

  collaborator OTHER

• Azienda Ospedaliera di Perugia

  collaborator OTHER

• Ospedale dell'Angelo, Venezia-Mestre

  collaborator OTHER

• Azienda Ulss 2 Marca Trevigiana

  collaborator OTHER

• Cardarelli Hospital

  collaborator OTHER

• Azienda Ospedaliera dei Colli

  collaborator OTHER

• IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

  collaborator OTHER

• Istituto Giannina Gaslini

  collaborator OTHER

• Istituti Ospitalieri di Cremona

  collaborator OTHER

• IRCSS Lazzaro Spallanzani, Roma

  collaborator UNKNOWN

• ASST Santi Paolo e Carlo

  collaborator OTHER

• ASST Valtellina e Alto Lario

  collaborator UNKNOWN

• Azienda USL Toscana Sud Est

  collaborator OTHER_GOV

• ULSS1 Dolomiti, Belluno

  collaborator UNKNOWN

• Asst Degli Spedali Civili Di Brescia

  collaborator OTHER

• IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo

  collaborator UNKNOWN

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS

  collaborator OTHER

• Ospedale Luigi Curto, Polla

  collaborator UNKNOWN

• Istituto Auxologico Italiano

  collaborator OTHER

• CEINGE Biotecnologie Avanzate, Napoli

  collaborator UNKNOWN

• University of Siena

  lead OTHER

Principal Investigators

• Francesca Mari, MD, PhD · University of Siena

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-04-08

Primary Completion

2022-12-31

Completion

2026-04-08

Countries

• Italy

Study Locations