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Equity and Efficacy of Allocation Priority for Liver Transplantation Patients With MELD≥30 in Italy

NCT04530240 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 4238

Last updated 2020-08-28

No results posted yet for this study

Summary

In Italy, since August 2014, liver transplantation (LT) candidates with MELD≥30 receive a priority allocation consenting them to access in an organ sharing macroarea. The primary intent of this policy is to minimize the higher risk of waiting list dropout observed in these patients. Another objective of this allocation strategy is to reduce the waiting time, thus performing the LT in better clinical conditions. This multicentre retrospective national study aims to evaluate several parameters of efficacy and equity, such as waiting time in the list, dropout rate, and graft survival, in two eras of enlisted patients, before and after the introduction of the macroarea sharing policy in Italy. With the intent to minimize the presence of possible selection biases, the two groups were matched trough Propensity Score Matching (PSM).

Conditions

  • Liver Transplant Disorder
  • HCC

Interventions

PROCEDURE

Liver Transplantation

Use prospectively collected databases from each participate centre, register MELD score recorded at the time of drop-out, liver transplantation and end of the follow-up.

Sponsors & Collaborators

  • University of Roma La Sapienza

    collaborator OTHER

  • University of Pisa

    collaborator OTHER

  • A.O.U. Città della Salute e della Scienza

    collaborator OTHER

  • Niguarda Hospital

    collaborator OTHER

  • Catholic University of the Sacred Heart

    collaborator OTHER

  • University of Bologna

    lead OTHER

Principal Investigators

  • Matteo Ravaioli, Professor · Sant'Orsola-Malpighi Hospital, University of Bologna

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-08-01
Primary Completion
2018-08-31
Completion
2019-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04530240 on ClinicalTrials.gov