Early Allograft Failure Simplified Estimation (EASE) in Liver Transplantation

Summary

A variety of clinical scores have been developed with the intent to predict early allograft failure after liver transplantation. With the present study the investigators aim to validate the recently published L-GrAFT Score on a multicenter cohort from 14 liver transplant centers in Italy.

Secondly, after identifying coefficients which are peculiar for the Italian transplant population, the investigators aim to develop a novel, simplified model for the estimation of early allograft failure (EASE Score).

Thirdly, the investigators plan to validate the EASE Score on a population from two liver transplant centers in the United Kingdom.

Conditions

• Liver Transplant Failure

Interventions

PROCEDURE

Liver transplantation

Liver transplantation from deceased donors

Sponsors & Collaborators

• Azienda Ospedaliero, Universitaria Pisana

  collaborator OTHER

• The Mediterranean Institute for Transplantation and Advanced Specialized Therapies

  collaborator OTHER

• University Hospital Padova

  collaborator OTHER

• Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

  collaborator OTHER

• A.O. Ospedale Papa Giovanni XXIII

  collaborator OTHER

• Ospedali Riuniti Ancona

  collaborator OTHER

• Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

  collaborator OTHER

• Azienda Ospedaliero-Universitaria di Modena

  collaborator OTHER

• University of Roma La Sapienza

  collaborator OTHER

• Azienda Ospedaliera Universitaria Integrata Verona

  collaborator OTHER

• IRCCS Azienda Ospedaliero-Universitaria di Bologna

  collaborator OTHER

• Azienda Ospedaliera Niguarda Cà Granda

  collaborator OTHER

• A.O.U. Città della Salute e della Scienza

  collaborator OTHER

• University Hospital Birmingham NHS Foundation Trust

  collaborator OTHER

• Newcastle-upon-Tyne Hospitals NHS Trust

  collaborator OTHER

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS

  lead OTHER

Principal Investigators

• Alfonso W Avolio, MD · [email protected]

Eligibility

Min Age

18 Years

Max Age

73 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-06-15

Primary Completion

2018-11-28

Completion

2019-01-10

Countries

• Italy

Study Locations