Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism

Summary

The purpose of this study is to determine whether identification of misfolded proteins in the skin will help to determine what sort of parkinsonism someone has. We seek to demonstrate whether someone has a synucleinopathy such as Parkinson's disease (PD), multiple system atrophy (MSA), or dementia with Lewy bodies(DLB), as opposed to a tauopathy such as progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD) or no parkinsonism at all (control).

Conditions

• Parkinson Disease
• Parkinsonism
• Dementia With Lewy Bodies
• Multiple System Atrophy
• Progressive Supranuclear Palsy
• Corticobasal Degeneration

Interventions

PROCEDURE

punch skin biopsy

An anesthetic medication is injected to numb the areas of skin and two samples of skin are obtained from punch biopsy.

Sponsors & Collaborators

• Case Western Reserve University

  collaborator OTHER

• National Institute of Neurological Disorders and Stroke (NINDS)

  collaborator NIH

• National Institute of Allergy and Infectious Diseases (NIAID)

  collaborator NIH

• Banner Health

  collaborator OTHER

• University of Bologna

  collaborator OTHER

• Universidad Autonoma de San Luis Potosí

  collaborator OTHER

• University Hospitals Cleveland Medical Center

  lead OTHER

Principal Investigators

• Steven Gunzler, MD · University Hospitals Cleveland Medical Center and Case Western Reserve University

• Chen Shu, PhD · University of Alabama at Birmingham

• Zerui Wang, MD, PhD · Case Western Reserve University

• Qingzhong Kong, PhD · Case Western Reserve University

Eligibility

Min Age

21 Years

Max Age

89 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-03-12

Primary Completion

2025-05-31

Completion

2025-05-31

Countries

• United States

Study Locations