MedTrace Logo

Parkinson's Disease Biomarker Study

NCT06812702 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 230

Last updated 2026-03-13

No results posted yet for this study

Summary

The primary objective of this study is to determine whether data acquired from a remote monitoring approach can reliably identify and track motor symptoms in prodromal PD and clinical PD.

The study is a one-year longitudinal biomarker study recruiting idiopathic RBD patients, Parkinson's Disease patient and healthy controls. All participants receive a smartphone with the Roche PD Mobile Application, complete a number of active tests daily and their movements will be remotely monitored. Participants will undergo additional neurological exams and DaT-SPECT and MRI imaging in the study.

A second objective of this study will be to validate an immunohistochemistry skin biopsy assay for the detection of pathological alpha-synuclein diagnostic of PD, in the peripheral nerves of the skin.

Conditions

  • Parkinson Disease, Idiopathic
  • REM Sleep Behavior Disorder

Interventions

OTHER

Observational

Observational

PROCEDURE

Skin Biopsy

Participants may consent to additional skin biopsy at baseline and at the one-year follow-up. Skin will be taken paravertebrally at approximately the C8 level.

Sponsors & Collaborators

  • Ronald Postuma

    lead OTHER

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-05
Primary Completion
2025-12-31
Completion
2026-03-01

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06812702 on ClinicalTrials.gov