ZW25 in Women With Endometrial Cancers
NCT04513665 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 16
Last updated 2025-05-22
Summary
This study is being done to test the drug ZW25 and look at whether this drug is effective in women with HER2-overexpressed endometrial cancer or carcinosarcoma that has been treated in the past.
Conditions
- Endometrial Cancer
- Carcinosarcoma
Interventions
- DRUG
-
ZW25
ZW25 at 20mg/kg intravenously (IV) every two weeks.
Sponsors & Collaborators
-
Zymeworks BC Inc.
collaborator INDUSTRY -
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Vikky Makker, MD · Memorial Sloan Kettering Cancer Center
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-08-12
- Primary Completion
- 2024-03-08
- Completion
- 2024-03-08
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Liposomal Doxorubicin in Treating Patients With Advanced or Recurrent Endometrial Cancer
NCT00005861 ·Status: COMPLETED ·Phase: PHASE2
-
AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma
NCT03668340 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Letrozole in Treating Women With Recurrent or Metastatic Endometrial Cancer
NCT00004251 ·Status: COMPLETED ·Phase: PHASE2
-
Topotecan in Treating Patients With Recurrent or Refractory Cancer of the Uterus
NCT00003156 ·Status: TERMINATED ·Phase: PHASE2
-
Gemcitabine in Treating Patients With Recurrent or Refractory Cancer of the Uterus
NCT00003316 ·Status: TERMINATED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Recurrent or Advanced Cancer of the Uterus
NCT00002993 ·Status: TERMINATED ·Phase: PHASE2
-
Chemotherapy in Treating Patients With Sarcoma of the Uterus
NCT00005643 ·Status: COMPLETED ·Phase: PHASE2
-
Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer
NCT02549989 ·Status: COMPLETED ·Phase: PHASE2
-
Ixabepilone in Treating Patients With Recurrent or Persistent Endometrial Cancer
NCT00095979 ·Status: COMPLETED ·Phase: PHASE2
-
Intraperitoneal Paclitaxel, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Stage III-IV Endometrial Cancer
NCT00575952 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Trial of PM00104 (Zalypsis®) in Patients With Advanced and/or Metastatic Endometrial or Cervical Cancer Previously Treated With One Line of Systemic Chemotherapy
NCT00900562 ·Status: TERMINATED ·Phase: PHASE2
-
Pazopanib Hydrochloride in Treating Patients With Recurrent or Persistent Uterine Cancer
NCT01247571 ·Status: COMPLETED ·Phase: PHASE2
-
Topotecan in Treating Patients With Gynecologic Cancer That Cannot Be Removed by Surgery
NCT00842452 ·Status: COMPLETED ·Phase: PHASE1
-
Gefitinib in Treating Patients With Persistent or Recurrent Endometrial Cancer
NCT00027690 ·Status: COMPLETED ·Phase: PHASE2
-
Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer
NCT02065687 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Docetaxel in Treating Patients With Recurrent or Persistent Endometrial Carcinoma (Cancer)
NCT00085332 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Pembrolizumab With Lenvatinib in Women With Advanced Uterine Carcinosarcoma
NCT05147558 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
BEZ235 Trial in Patients With Advanced Endometrial Carcinoma
NCT01290406 ·Status: WITHDRAWN ·Phase: PHASE2
-
Trabectedin in Treating Patients With Advanced, Persistent, or Recurrent Leiomyosarcoma of the Uterus
NCT00379145 ·Status: COMPLETED ·Phase: PHASE2
-
Study of BMS-986205 and Nivolumab in Endometrial Cancer or Endometrial Carcinosarcoma That Has Not Responded to Treatment
NCT04106414 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer
NCT02728258 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of GDC-0980 in the Treatment of Recurrent or Persistent Endometrial Carcinoma
NCT01455493 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine in Treating Patients With Recurrent or Persistent Endometrial Cancer
NCT00820898 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Durvalumab With or Without Tremelimumab in Endometrial Cancer
NCT03015129 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Cancer
NCT00003732 ·Status: COMPLETED ·Phase: PHASE2