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A Real World Study on Clinical Efficacy of Bicarbonate Ringer's Solution in Biliary Atresia Children

NCT04506021 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2020-08-10

No results posted yet for this study

Summary

In most babies with biliary atresia (BA) bile ducts on the inside and outside of the liver are affected eventually leading to a complete blockage of bile flow from the liver. This in turn causes scarring (fibrosis) in the liver. The surgery called the Kasai procedure and eventually, a liver transplant could treat biliary atresia. However, children with BA have poor liver function, poor renal reserve, and poor ability to regulate water and electrolytes. Therefore, A reasonable and effective perioperative fluid management is more significant. Considering the high chlorine of saline, the liver burden of Lactated Ringer's solution and Acetated Ringer's solution, the Bicarbonate Ringer's solution which composition is similar to plasma, could be the best choice for perioperative fluid management of BA children. Therefore, we hypothesize that compared with other crystalloids, Bicarbonate Ringer's solution is a better choice to maintain water, electrolyte and acid-base balance in BA children.

Conditions

  • Biliary Atresia

Interventions

DRUG

Bicarbonate Ringer's solution

According to the choices of the patients' immediate family members, patients will be divided into Bicarbonate Ringer's Solution. no Intervention.

DRUG

Other Crystalloid

According to the choices of the patients' immediate family members, patients will be divided into other clinical used crystalloid. no Intervention.

Sponsors & Collaborators

  • Tongji Hospital

    lead OTHER

Principal Investigators

  • Jiexiong Feng · Tongji hospital of huazhong university of science and technology

Eligibility

Max Age
90 Days
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-31
Primary Completion
2021-08-31
Completion
2021-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04506021 on ClinicalTrials.gov