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High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure

NCT02718079 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2019-11-20

No results posted yet for this study

Summary

The study will be conducted on patients admitted to Department of Hepatology from Jan 2016 to Jan 2018 at Institute of Liver \& Biliary Sciences, New Delhi. Study group will comprise of patients with acute liver failure (ALF) who have no option for liver transplant (due to any reason) or have contraindications for liver transplant or have no prospective living donor and will be assessed for enrollment in the trial.

Conditions

  • Acute Liver Failure

Interventions

BIOLOGICAL

Plasma Exchange

OTHER

Management of cerebral edema/intracranial hypertension:

OTHER

Transfer to Intensive Care Unit

DRUG

Prophylactic Antibiotics

OTHER

Intubation of trachea

OTHER

Administration of mannitol or 3% saline for severe elevation of Intra Cranial Pressure

OTHER

Volume Replacement

OTHER

Pressor Support

DRUG

N-acetyl-L-cysteine

OTHER

Correction of metabolic parameters

DIETARY_SUPPLEMENT

Correction of nutrition

Sponsors & Collaborators

  • Institute of Liver and Biliary Sciences, India

    lead OTHER

Principal Investigators

  • Dr Rakhi Maiwall, DM · Institute of Liver and Biliary Sciences

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
12 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-30
Primary Completion
2018-10-08
Completion
2018-10-18

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02718079 on ClinicalTrials.gov