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Autonomic Cardiovascular Control in Response to Blood Volume Reduction in Blood Donors

NCT04499664 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2022-08-30

No results posted yet for this study

Summary

The function of the autonomic nervous system can be assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV). Decreased HRV has been shown to be predictive of morbidity and mortality in diverse medical conditions such as acute myocardial infarction, aneurysmal subarachnoid haemorrhage, autoimmune diseases, sepsis and surgery.

The function of the autonomic nervous system has not yet been investigated in a "pure hypovolemia" model. The aim of the current study is therefore to investigate and describe the function of the autonomic nervous system prior to, during and after reduction of blood volume in healthy blood donors.

Conditions

  • Autonomic Dysfunction
  • Autonomic Imbalance
  • Blood Loss

Interventions

DEVICE

Monitoring of the autonomic nervous system

Monitoring of the autonomic nervous system using E-patch, LiDCO and Root-Massimo.

Sponsors & Collaborators

  • Hvidovre University Hospital

    lead OTHER

Principal Investigators

  • Henrik Kehlet, Professor · Rigshospitalet, Denmark

Eligibility

Min Age
30 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-08-01
Primary Completion
2020-09-01
Completion
2022-06-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04499664 on ClinicalTrials.gov