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Shear Wave Elastography

NCT04493346 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 14

Last updated 2023-01-26

No results posted yet for this study

Summary

In individuals needing a left ventricular assist device (LVAD), right heart failure (RHF) is a serious complication post-surgery, associated with worsened outcomes including mortality. However, predictors of decompensation after LVAD are not well established. Liver dysfunction pre-LVAD has been shown to be associated with poor outcomes post-LVAD, but the interplay between liver abnormalities and RHF post-LVAD is not well characterized. Liver stiffness (LS) is a measure associated with certain types of liver abnormalities (e.g., liver fibrosis; cirrhosis).

Thus, we hypothesize that elevated LS measured by SWE is associated with increased morbidity and mortality in patients undergoing LVAD implantation and yields increased need for advanced postoperative HF therapies including the use of right ventricular assist devices (RVAD) for the management of RHF.

Conditions

  • Heart Failure
  • Transplant; Failure, Heart
  • Decompensated Heart Failure
  • Fibrosis, Liver
  • Cirrhosis, Liver

Sponsors & Collaborators

  • Baylor Research Institute

    lead OTHER

Principal Investigators

  • Amarinder Bindra, MD · BSWHRI

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-21
Primary Completion
2022-04-11
Completion
2022-04-11

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04493346 on ClinicalTrials.gov