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Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects

NCT04482738 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2022-03-23

No results posted yet for this study

Summary

Investigators suggest that in lean subjects cortisol increases in response to overfeeding and that this increase is blunted in obese subjects. A group of 18 male healthy lean subjects and another group of 18 male healthy obese subjects will undergo a high-calorie meal test. Prior to the meal intake, an indirect calorimetry, bioelectrical impedance, heart rate variability, a fasting blood sample and a perceived stress questionnaire will be assessed. After intake of the study meal, blood tests will be performed in order to measure the secretion of cortisol, glucose and lipid metabolism and inflammatory markers. Indirect calorimetry will be assessed again 60 and 180 minutes after the meal intake.

Conditions

  • Overweight and Obesity

Interventions

OTHER

High-calorie meal

Intake of a high-calorie meal (2500-3000 calories) within 15 minutes.

Sponsors & Collaborators

  • Novartis

    collaborator INDUSTRY

  • Eleonora Seelig

    lead OTHER

Principal Investigators

  • Eleonora Seelig, MD · University Hospital, Basel, Switzerland

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-05-14
Primary Completion
2021-02-20
Completion
2021-02-20

Countries

  • Switzerland

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04482738 on ClinicalTrials.gov