Targeting HIV Retention and Improved Viral Load Through Engagement ('THRIVE')

Summary

Many people with HIV infection are not consistently engaged in outpatient HIV care, and avoidance, stigma and denial contribute to poor engagement in HIV care. This project will develop and pilot test a new intervention, "THRIVE," for hospitalized persons who are out of HIV care and endorse avoidance, to improve how well they stay in outpatient HIV care after discharge. If successfully developed, the intervention will undergo large scale testing in later studies and could improve the health of persons with HIV infection and help end the HIV epidemic in the United States.

Conditions

• Human Immunodeficiency Virus
• Depression
• Anxiety

Interventions

BEHAVIORAL

THRIVE

The ACT components (3-3.5 hours) will focus on clarifying patient values and goals and identifying obstacles that may be getting in the way of living a rich life. Short-and long-term effects of avoidance will be discussed (e.g., avoidance reduces immediate contact with distressing experiences and provides short-term relief but leads to greater dysfunction in long run). Patients will be taught acceptance, mindfulness, and perspective taking to help patient cope with difficult emotions and thoughts that may interfere with living a values-driven life. Individuals will also be encouraged to examine the costs of stigmatization on their life (e.g. avoidance of medical care, sense of isolation). Education will include medical information about HIV, services available at the clinic, and health needs related to comorbidities. This content to be delivered in 30 minutes.

OTHER

Treatment as Usual

Patients get usual care at the hospital. Service linkage workers (SLWs) meet with all hospitalized PWH and cover educational aspects of the care.

Sponsors & Collaborators

• University of Iowa

  collaborator OTHER

• Brown University

  collaborator OTHER

• University of Texas

  collaborator OTHER

• National Institute of Mental Health (NIMH)

  collaborator NIH

• Baylor College of Medicine

  lead OTHER

Principal Investigators

• Lilian Dindo, Ph.D · Baylor College of Medicine

• Thomas Giordano, M.D., M.P.H. · Baylor College of Medicine

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-03-03

Primary Completion

2024-02-29

Completion

2024-02-29

Countries

• United States

Study Locations