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Effects of Fasting-Mimicking Diet on Central and Peripheral Components of Fatigue, Muscular Resistance

NCT04476615 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2020-07-20

No results posted yet for this study

Summary

The aim of the study is to test a Fasting Mimicking Diet (FMD) for its efficacy on improving muscular resistance and endurance. The investigators will perform a randomized clinical trial to test the efficacy of the FMD on improving muscular strength, muscular resistance and endurance in physically active young adults (18-40 years of age). The study will include two arms: Placebo (Placebo diet) and FMD (3 cycles of 5-day fasting-mimicking diet within two months). Study endpoints will include muscular strength evaluation of lower limbs, cardio-pulmonary responses, neuromuscular function and muscle architecture. Subjects will be evaluated 4 times within 3 months: at baseline (T1), after the 1st cycle of diet (T2), 7 to 15 days after the 3rd cycle of diet maintaining baseline intensity (T3) and with re-assessment of Peak Power Output (T4).

Conditions

  • Fatigue; Muscle, Heart
  • Fasting
  • Diet, Healthy
  • Fatigue, Mental

Interventions

DIETARY_SUPPLEMENT

Fasting-Mimicking Diet (ProLon®)

Dietary restriction: Fasting-Mimicking Diet (ProLon®). 5-days cycles spaced at 1-month intervals for 3 months (3 cycles in total).

DIETARY_SUPPLEMENT

Placebo bars

Dietary supplementation: Low-energy bars (L-Nutra®) to integrate the daily nutritional habits - one bar per day. 5-days cycles spaced at 1-month intervals for 3 months (3 cycles in total).

Sponsors & Collaborators

  • University of Southern California

    collaborator OTHER

  • Universita di Verona

    lead OTHER

Principal Investigators

  • Matteo Bertucco, PhD · Department of Neurosciences, Biomedicine and Movement Sciences - University of Verona

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-12-04
Primary Completion
2020-01-16
Completion
2020-01-16

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04476615 on ClinicalTrials.gov