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Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics

NCT04475900 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 372

Last updated 2022-08-11

No results posted yet for this study

Summary

The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with biomechanical alterations of the cornea. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. In glaucoma, the information about corneal alterations serves in two ways, first, correct measurement of intra ocular pressure (IOP); second, early diagnosis of suspects before visual field defects are detectable.

Especially, the Corvis ST is an air-puff tonometer that measures intraocular pressure, corneal thickness (CCT) as well as dynamic corneal response (DCR) parameters. Most of the DCR parameters are affected by IOP and CCT: Therefore, algorithm are needed to determine parameters without impact of IOP and CCT that are describe the biomechanical properties of the cornea.

Conditions

Interventions

DIAGNOSTIC_TEST

Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany)

To measure corneal biomechanics with Scheimpflug based tonometry

DIAGNOSTIC_TEST

Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany)

To measure corneal topography and tomography with Scheimpflug tomograph

DIAGNOSTIC_TEST

Optic nerve head measurement

To measure optic nerve excavation

Sponsors & Collaborators

  • Fraunhofer Institute for Ceramic Technologies and Systems IKTS

    collaborator UNKNOWN

  • Technische Universität Dresden

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-07-09
Primary Completion
2022-04-30
Completion
2022-07-31
FDA Device
Yes

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04475900 on ClinicalTrials.gov