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Low Versus High Corticosteroid Use in Ventilator Associated Pneumonia

NCT04467892 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2020-07-13

No results posted yet for this study

Summary

patients who had \>3 on Murray score and \>6 on CPIS allocated randomly in two groups 120 patients in each. Group A received 30 mg/kg methyl-prednisolone slowly intravenous in 250 mL normal saline every 8 hours for only 48 hours while group B received 1 mg/kg/day methyl-prednisolone divided to three doses given every 8 hours for two weeks. Duration of the study last 16 days, Morbidity considered if no improvement in any or all clinical parameters of both Murray and CPIS scores and failure of weaning of patients from the ventilator at the studied period.

Conditions

  • Ventilator Associated Pneumonia

Interventions

DRUG

methylprednisolone

received high dose (30 mg/kg) methylprednisolone slowly intravenous in 250 ml normal saline every 8 hours for only 4 days

DRUG

Methyl Prednisolonate

received 1 mg/kg/day methylprednisolone divided to three doses given every 8 hours for two weeks.

DEVICE

ventilators

all patients in both groups will be ventilated with CMV for 2 weeks

Sponsors & Collaborators

  • King Abdul Aziz Specialist Hospital

    lead NETWORK

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-02
Primary Completion
2020-02-14
Completion
2020-02-25

Countries

  • Saudi Arabia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04467892 on ClinicalTrials.gov