Mechanisms of Increased Disease Severity in AD Patients With the IL-4Ra R576 Polymorphism
NCT04455906 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 111
Last updated 2026-05-18
Summary
This protocol is primarily looking to see if the IL-4Ra R576 polymorphism is associated with increased clinical, immunological and microbial markers of disease activity in patients with Atopic dermatitis.
Conditions
Sponsors & Collaborators
-
National Institute of Allergy and Infectious Diseases (NIAID)
collaborator NIH - lead OTHER
Principal Investigators
-
Wanda Phipatanakul, MD. MS. · Boston Children's Hospital
Eligibility
- Min Age
- 6 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-11-30
- Primary Completion
- 2027-03-15
- Completion
- 2027-09-15
Countries
- United States
Study Locations
More Related Trials
-
Observational Evaluation of Atopic Dermatitis in Pediatric Patients
NCT03687359 ·Status: ACTIVE_NOT_RECRUITING
-
Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients
NCT06397781 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Reversal of Epidermal Phenotype in Severe Atopic Dermatitis With Cyclosporine Therapy
NCT01149759 ·Status: COMPLETED ·Phase: NA
-
Atopic Dermatitis (AD) and Food Allergy
NCT03168113 ·Status: COMPLETED
-
Molecular Signatures of Cutaneous Dupilumab Response
NCT05858619 ·Status: RECRUITING ·Phase: PHASE4
-
Knowledge Base in the Treatment of Atopic Dermatitis Among Thai Pediatricians
NCT01069666 ·Status: COMPLETED
-
The Study of CM326 in Moderate-to-severe Atopic Dermatitis
NCT05671432 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety and Efficacy of SRD441 Ointment in Patients With Atopic Dermatitis
NCT00882245 ·Status: COMPLETED ·Phase: PHASE2
-
Asthma, Missed Immunizations, and Vitamin D Deficiency in Atopic Dermatitis
NCT01234909 ·Status: TERMINATED
-
A Study of AK120 (IL-4Rα) in Healthy Subjects and Subjects With Moderate- to- Severe Atopic Dermatitis
NCT04256174 ·Status: COMPLETED ·Phase: PHASE1
-
A Multi-Center Study of Short and Long-term Use of Protopic Ointment in Patients With Atopic Dermatitis
NCT00106496 ·Status: COMPLETED ·Phase: PHASE4
-
Phase 2 Study of SAR444656 in Adult Participants With Moderate to Severe Atopic Dermatitis
NCT06058156 ·Status: TERMINATED ·Phase: PHASE2
-
A Study Evaluating the Safety and Efficacy of QGE031 in Atopic Dermatitis Patients
NCT01552629 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy Study of Montelukast in Atopic Dermatitis Induced by Food Allergens
NCT00557284 ·Status: COMPLETED ·Phase: PHASE4
-
CLINICAL EFFICACY OF EMOLLIENTS IN ATOPIC DERMATITIS PATIENTS
NCT05783453 ·Status: COMPLETED
-
A Study to Assess the Effects of Nemolizumab on Cytochrome P450 Substrates in Participants With Moderate-to-Severe Atopic Dermatitis
NCT04562116 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluating Skin Barrier Dysfunction in Infants at High Risk of Atopy
NCT03089476 ·Status: WITHDRAWN ·Phase: NA
-
Disease Trajectories and Anti-cytokine Response Signatures in Atopic Dermatitis and Psoriasis
NCT03361215 ·Status: RECRUITING
-
Effect of Methotrexate on Inflammatory Response in Adult Atopic Dermatitis Patients
NCT03327116 ·Status: COMPLETED ·Phase: NA
-
KM110329 in Adult Patients With Atopic Dermatitis
NCT01692093 ·Status: UNKNOWN ·Phase: PHASE2
-
The Transcriptomic Study of Thai Patients With Atopic Dermatitis by Tape Strips
NCT05598762 ·Status: UNKNOWN ·Phase: NA
-
Prospective Longitudinal Observational Research in Atopic Dermatitis
NCT04240522 ·Status: RECRUITING
-
Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis
NCT03389893 ·Status: TERMINATED ·Phase: PHASE4
-
Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals
NCT00001760 ·Status: COMPLETED
-
A Study of Oral Upadacitinib Tablets to Assess Change in Disease State in Participants Aged 12-75 Years With Moderate to Severe Atopic Dermatitis in Brazil
NCT04666675 ·Status: WITHDRAWN ·Phase: PHASE3