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Bronchial Hyperreactivity in Atopic Dermatitis Patients - a 10 Year Follow-up

NCT00795496 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2011-04-20

No results posted yet for this study

Summary

The investigators will contact 64 patients with atopic dermatitis (AD) who participated in a long-term tacrolimus ointment trial in Helsinki 10 years ago, and ask them to participate in this follow-up study. The investigators will do the same tests as 10 years ago, i.e. bronchial hyperreactivity, skin prick tests, serum-IgE, Mantoux-test (2 TU), and questionnaires about asthma and allergic rhinitis symptoms. The investigators also collect data about their AD medication during the last 10 years.

The investigators hypothesis is that when the skin condition improves in patients with AD the brochial hyperreactivity improves. The investigators also want to study whether different treatments play a role in the development or resolution of bronchial hyperreactivity.

Conditions

Interventions

PROCEDURE

Histamine provocation

A dosimetric histamine challenge test in which the provocative dose of inhaled histamine producing a decrease of 15% in FEV1 is measured.

PROCEDURE

Skin prick tests

Skin prick testing will be performed for: birch, timothy, mugwort, alder, pine, cat, dog, horse, house dust mite, Cladosporium herbarum.

PROCEDURE

Serum IgE blood testing

One blood test to measure total serum IgE

PROCEDURE

Mantoux-testing

Tuberculin (2 TU) s.c. on the forearm. The test is read after 72 hours.

Sponsors & Collaborators

  • University of Helsinki

    lead OTHER

Principal Investigators

  • Sakari Reitamo, MD, PhD · Skin- and Allergy Hospital, Dep. of Dermatology

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2010-04-30
Completion
2010-08-31

Countries

  • Finland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00795496 on ClinicalTrials.gov