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Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

NCT04441112 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2020-06-22

No results posted yet for this study

Summary

Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

Conditions

  • Arthritis Knee
  • Arthritis of Hip

Interventions

DRUG

Ketorolac Intraarticular Injection

Injections will be given under ultrasound guidance with one of two possible medications.

DRUG

Triamcinolone Intraarticular Injection

Injections will be given under ultrasound guidance with one of two possible medications.

Sponsors & Collaborators

  • Saint Alphonsus Regional Medical Center

    lead OTHER

Principal Investigators

  • Kevin Jurgensmeier, BS · Student Investigator at Saint Alphonsus Regional Medical Center

  • Steven B Daines, MD · Surgeon at Saint Alphonsus Regional Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-05-20
Primary Completion
2019-08-20
Completion
2019-08-20
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04441112 on ClinicalTrials.gov