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Anemia in Non-celiac Wheat Sensitivity

NCT04377061 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 244

Last updated 2022-02-07

No results posted yet for this study

Summary

In recent years, a new gluten- or wheat-related disease has emerged, a condition labelled "non-celiac gluten sensitivity" (NCGS) or "non-celiac wheat sensitivity" (NCWS). This is very often a self-reported condition, since patients refer to intestinal \[mainly irritable bowel syndrome (IBS)-like\] and/or extra-intestinal symptoms (i.e. fatigue, headache, anemia) caused by gluten or wheat ingestion, even though they do not suffer from celiac disease (CD) or wheat allergy (WA).

Among the extra-intestinal symptoms, several studies have shown, in patients with NCWS, the presence of anemia, generally mild, often with iron or folate deficiency characteristics, but no research has ever been planned with the specific intention of analyze this particular aspect of the disease.

Therefore, the aim of the present multicentric research was to analyze, both retrospectively and prospectively, the laboratory data of NCWS patients, compared to CD and IBS controls, to identify: a) the presence, severity and morphologic characteristic of anemia; 2) possible pathogenic mechanisms.

Conditions

  • Non-celiac Gluten Sensitivity
  • Anemia

Interventions

DIAGNOSTIC_TEST

Evaluation of anemia

Evaluation of anemia in NCWS patients, and in CD and IBS controls, with both retrospective and prospective method.

Sponsors & Collaborators

  • University of Palermo

    lead OTHER

Principal Investigators

  • Pasquale Mansueto, MD · University of Palermo

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-01
Primary Completion
2021-01-01
Completion
2022-01-01

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04377061 on ClinicalTrials.gov