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Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue

NCT04374006 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2021-04-01

No results posted yet for this study

Summary

This study aims to evaluating inflammatory and apoptotic activity in rat's endometriosis lesion treated by Propolis compared to Dienogest

Conditions

  • Endometriosis; Peritoneum
  • Endometriosis

Interventions

DRUG

Dienogest

1mg/kg BW/day based on the study by Katayama et al. A DNG in 0,5% carboxymethylcellulose suspension was given orally with metal sound daily 0,2-0,4 mL per day

DRUG

Propolis

The propolis contains 20 mg in each ml. So, each rat we given 0,2 ml for 50mg/kg propolis treatment and 0,4 ml for 100mg/kg propolis treatment

OTHER

placebo

we gave 0,2 ml to each rat everyday to negative control groups, and we gave no treatment to sham groups

Sponsors & Collaborators

  • Indonesia University

    lead OTHER

Principal Investigators

  • Wachyu Hadisaputra, Prof, dr, SpOG · Lecturer at Obgyn Department, Indonesia University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-01
Primary Completion
2020-05-18
Completion
2020-05-18

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04374006 on ClinicalTrials.gov