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The Role of Lipids in Immune Cell Function in SLE Patients

NCT04361734 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2020-04-24

No results posted yet for this study

Summary

The overall aim of this project is to investigate the different types of immune cells found in the blood of patients with Systemic Lupus Erythematosus (SLE) and healthy donors. We know that the amount of fat on the surface of immune cells is an important factor controlling their behaviour. Immune cells from SLE patients are defective and this is associated with changes in the levels of fat on these cells. This project will investigate the level of fat in the blood and on immune cells from patients with SLE and age matched healthy controls, and measure how changes in the amount of fat can affect the way immune cells behave.

Conditions

  • Lupus Erythematosus, Systemic

Interventions

OTHER

Blood sampling to include Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA)

* Blood sampling to measure immune cell phenotypes and examine DNA/RNA and identify serum biomarkers. * Food Frequency Questionnaires (FFQs) and/or diet recall questionnaires to assess dietary intake. * Cardiovascular Ultrasound Scans (USS) to measure how well blood is carried around the body.

Sponsors & Collaborators

  • University College London Hospitals

    collaborator OTHER

  • University College, London

    lead OTHER

Principal Investigators

  • David Isenberg, Prof · UCL & University College London Hospitals NHS Foundation Trust

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-02-15
Primary Completion
2020-08-31
Completion
2020-08-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04361734 on ClinicalTrials.gov