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IL17 in Systemic Lupus Erythematosus Patients: Association With Disease Activity and Organ Damage

NCT05045417 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 140

Last updated 2021-09-16

No results posted yet for this study

Summary

Many laboratory markers can be measured for assessment of Lupus activity as aberrant manufacturing and imbalance of the cytokines of T-helper cell which already have been implicated within autoimmunity pathogenesis as IL-18 and IL-10 levels are usually elevated in lupus sufferers and correlated with SLEDAI score IL-17 has been linked to immune-mediated organ damage in several autoimmune diseases and recently it has been linked to pathogenesis of a murine model of lupus and human lupus Diverse cytokine abnormalities which common in lupus patients may skew T cells differentiation into IL-17-producing CD4+ and double negative T cells. This could promote the autoimmune process by activation of immune cells \&stimulation of proliferation of B-cell and production of antibody

Conditions

Interventions

DIAGNOSTIC_TEST

Serum level of IL-17

Measurement of serum level of IL-17 : 1. To explore the role of IL-17 in systemic lupus erythematosus 2. To determine the relation between IL-17 and lupus disease activity 3. To analyze the correlation between IL-17 and internal organ affection (lupus nephritis , interstitial lung disease)

Sponsors & Collaborators

  • Sohag University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2022-04-30
Completion
2022-04-30

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05045417 on ClinicalTrials.gov