How Does Patients' Overall Assessment of Their Health Vary Across and Within Different Disease Groups?

Summary

EQ-5D is one of the most commonly employed patient-reported outcome (PRO) measures. It is included in many of the Swedish National Quality Registers (NQRs). EQ-5D health states are usually summarized using 'values' obtained from healthy members of the general public. However an alternative - which remains to be studied in detail - is the potential to use patients' self-reported overall health on the visual analogue scale as a means of capturing experience-based values. The overall aim of this project is to increase knowledge on the potential applicability of EQ VAS as a health state valuation method through assessment of its variability across and within patient groups and compared with that of the general population in Sweden.

Data on nearly 700,000 patients from 12 NQRs covering a variety of diseases/conditions and from the general population will be analysed. Longitudinal studies of PROs among different patient groups will be conducted at baseline/first visit and 1-year follow-up. Descriptive analyses comparing EQ-5D health states and observed self-assessed EQ VAS within and across registers will be performed. Comparisons of the change in health state and observed EQ VAS values over one year will also be made. Regression models will be used to assess whether EQ-5D dimensions predict observed EQ VAS values to investigate patient value sets in each NQR. These will be compared across the patient groups and with the existing Swedish experience-based VAS and time trade-off (TTO) value sets obtained from the general population. This research project will provide information on the variation among different patient groups in terms of self-reported health status through EQ VAS and comparison with the general population. Knowledge on the relative importance of different dimensions of the EQ-5D to different patient groups as well as the general population will be gained in this project. The possibility of getting value sets based on patients' self-reported EQ VAS values and their comparison with value sets from experience-based general population studies will be discussed.

Conditions

• Hip Disease
• Heart Failure
• Psoriasis
• Fractures, Bone
• Bipolar Disorder
• Respiratory Failure
• Knee Disease
• Knee Injuries
• Ankle Disease
• Spinal Disease
• Rheumatic Diseases
• Osteoarthritis

Sponsors & Collaborators

• Karolinska Institutet

  collaborator OTHER

• Linkoeping University

  collaborator OTHER_GOV

• Lund University

  collaborator OTHER

• Ryhov County Hospital

  collaborator OTHER

• Göteborg University

  collaborator OTHER

• Umeå University

  collaborator OTHER

• University of Melbourne

  collaborator OTHER

• Office of Health Economics, London

  collaborator UNKNOWN

• Vastra Gotaland Region

  lead OTHER_GOV

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-01-31

Primary Completion

2020-09-30

Completion

2020-09-30

Countries

• Sweden

Study Locations