LIBERATE Trial in COVID-19
NCT04334629 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL
Last updated 2023-07-25
Summary
The study aims to evaluate the reduction in severity and progression of lung injury with three doses of lipid ibuprofen in patients with SARS-CoV-2 infections.
Conditions
- Coronavirus
- Respiratory Distress Syndrome
- SARS-CoV Infection
Interventions
- DRUG
-
Lipid ibuprofen 200 mg
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Richard Beale, MD · Guy's and St Thomas' NHS Foundation Trust
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-05-26
- Primary Completion
- 2021-05-25
- Completion
- 2021-09-25
Countries
- United Kingdom
Study Locations
More Related Trials
-
Study Evaluating The Efficacy Of A Novel Ibuprofen Formulation On Fever In Patients With An Uncomplicated Acute Infection
NCT01035346 ·Status: TERMINATED ·Phase: PHASE3
-
Efficacy, Safety, and Pharmacokinetics of Intravenous Ibuprofen in Adult Febrile Patients
NCT01131000 ·Status: COMPLETED ·Phase: PHASE3
-
Bioequivalence Study Between Two Oral Formulations of Ibuprofen 800 mg Tablets Under Fasting Conditions
NCT00804440 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America
NCT01938144 ·Status: WITHDRAWN ·Phase: PHASE3
-
Ibuprofen 4% (w/v) Pivotal Bioequivalence Study
NCT03496324 ·Status: COMPLETED ·Phase: PHASE1
-
Ibuprofen, Acetaminophen and Dipyrone to Fever Control in Children
NCT01359020 ·Status: COMPLETED ·Phase: PHASE4
-
Bioequivalence Study Between Two Oral Formulations of Ibuprofen 800 mg Tablets Under Fed Conditions
NCT00803946 ·Status: COMPLETED ·Phase: PHASE1
-
Bioavailability of Ibuprofen Enantiomers Compared With Standard Brufen Sirup in Healthy Male Volunteers
NCT02182960 ·Status: COMPLETED ·Phase: PHASE1
-
Ibuprofen Bioavailability Study
NCT03180879 ·Status: COMPLETED ·Phase: PHASE1
-
A Relative BioavailabilityStudy Of Ibuprofen 40mg/ml (laboratórios Pfizer Ltda) In The Oral Suspension Form.
NCT01466517 ·Status: COMPLETED ·Phase: PHASE4
-
Adult Oral Ibuprofen Study for ED Pain Patients
NCT03441269 ·Status: COMPLETED ·Phase: PHASE4
-
Study Comparing the Efficacy of Two Ibuprofen Formulations
NCT00740857 ·Status: COMPLETED ·Phase: PHASE4
-
RIPT of Ibuprofen Topical Gel
NCT01787448 ·Status: COMPLETED ·Phase: PHASE1
-
Surveillance Trial to Evaluate a Shortened Infusion Time of Intravenous Ibuprofen
NCT01334944 ·Status: COMPLETED ·Phase: PHASE4
-
To Test Bioequivalence Between Two Formulations of Paracetamol/Phenylephrine
NCT01112462 ·Status: COMPLETED ·Phase: PHASE1
-
Bioequivalence Study of Ibuprofen 400 mg/10 mL Oral Suspension vs. MOMENTACT 400 mg Film-coated Tablet
NCT02902302 ·Status: COMPLETED ·Phase: PHASE1
-
PAIR (Paracetamol and Ibuprofen Research) Pilot Trial
NCT04986839 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Ibuprofen and Paracetamol Pharmacokinetic Study
NCT02452450 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetic Study Of Ibuprofen Injection (IVIb) In Healthy Adult Subjects
NCT00867880 ·Status: COMPLETED ·Phase: PHASE1
-
Back to the Traditional: Anti-COX Drugs Can Improve the Outcome of COVID-19 Patients Admitted to ICU
NCT04757792 ·Status: COMPLETED
-
A Bioequivalence Study Of Ibuprofen 50mg/ml (laboratórios Pfizer Ltda) In The Oral Suspension Form.
NCT01350596 ·Status: COMPLETED ·Phase: PHASE4
-
Actual Use and Compliance Study Of Ibuprofen 600 Mg Immediate Release/Extended Release Tablets In At-Risk OTC Consumers
NCT03722238 ·Status: TERMINATED ·Phase: PHASE3
-
Impact of Excipients on Pharmacokinetics of OXPzero(TM) Ibuprofen
NCT02974361 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Pharmacogenetic of Ibuprofen After Lower Third Molar Surgeries
NCT03169127 ·Status: UNKNOWN ·Phase: PHASE4
-
A Bioequivalence Study of Two Ibuprofen Arginine Granules 400 mg Formulations Under Fasting and Fed Conditions in Chinese Healthy Adult Subjects
NCT05737069 ·Status: COMPLETED ·Phase: PHASE1