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Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

NCT04332952 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 21

Last updated 2020-04-09

No results posted yet for this study

Summary

The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory.

The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

Conditions

  • Glycocalyx
  • Cardio-Renal Syndrome

Sponsors & Collaborators

  • Instituto Nacional de Cardiologia Ignacio Chavez

    collaborator OTHER

  • Miguel Ayala León

    lead NETWORK

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-01
Primary Completion
2017-10-01
Completion
2017-12-31

Countries

  • Mexico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04332952 on ClinicalTrials.gov