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The Relationship Between Obesity-related Molecular Typing and Traditional Chinese Medicine Constitution

NCT04326244 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-07-15

No results posted yet for this study

Summary

Obesity is an epidemic and a growing problem in the world. There are numerous causes of obesity, the most novel and personalized of which is genetic inheritance. Single nucleotide polymorphisms are the most common type of genetic variation among people, regulating the response between the diet and the body. Meanwhile, Traditional Chinese medicine pattern differentiation is also personalized and usually influenced by inheritance, living habits, character and environment and so on. The common constitutions in obesity are Qi deficiency, Yang Deficiency, and Phlegm dampness, which are correlated with oxygen, sugar and fat metabolism, also affected by gene expression. Therefore, the relationship between constitution, metabolism and genetic molecular typing may be significant in obesity with obstructive sleep apnea patients.

Conditions

Interventions

DIAGNOSTIC_TEST

blood test

High-density lipoprotein- cholesterol, Low-density lipoprotein- cholesterol, Total cholesterol, Triglyceride, Leptin, Glucose AC, Hemoglobin A1C, Insulin

DIAGNOSTIC_TEST

genetic test

FTO、MC4R、BDNF、PPARG、ADRB3、UCP1

DIAGNOSTIC_TEST

Constitution in Chinese Medicine Questionnaire

Constitution in Chinese Medicine Questionnaire

DIAGNOSTIC_TEST

Epworth Sleepiness Scale

Epworth Sleepiness Scale

DIAGNOSTIC_TEST

cephalometry

Evaluation of craniofacial morphology in OSA patients

DIAGNOSTIC_TEST

polysomnography

to evaluate Apnea-Hypopnea Index (AHI) for the severity of sleep apnea

Sponsors & Collaborators

  • Chang Gung Memorial Hospital

    lead OTHER

Principal Investigators

  • Kun-Hao Jiang · Chang Gung Memorial Hospital

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-10
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Taiwan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04326244 on ClinicalTrials.gov