Crizotinb or Standard Chemotherapy in Met Exon 14 Skipping Advanced NSCLC
NCT04322578 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 120
Last updated 2024-06-04
Summary
This study aims to explore the efficacy and safety of Crizotinb or Standard Chemotherapy in Met exon 14 skipping Advanced Non-small Cell Lung Cancer
Conditions
Interventions
- DRUG
-
Crizotinib 250mg po bid. Savolitinib 300mg po, qd.
- DRUG
-
Pemetrexed
Pemetrexed, 500mg/m2, ivgtt erery 21day.
Sponsors & Collaborators
-
Hunan Province Tumor Hospital
lead OTHER
Principal Investigators
-
Yongchang Zhang, MD · Hunan Cancer Hospital
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-03-24
- Primary Completion
- 2025-03-24
- Completion
- 2026-03-24
Countries
- China
Study Locations
More Related Trials
-
PD-1 Combined With Pyrotinib for Chemotherapy Failure HER2 Insertion Mutation Advanced NSCLC
NCT04144569 ·Status: RECRUITING ·Phase: PHASE2
-
Alternating Icotinib and Chemotherapy for Advanced Non-small Cell Lung Cancer With EGFR Mutation
NCT02737774 ·Status: UNKNOWN ·Phase: PHASE2
-
Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation
NCT04322890 ·Status: RECRUITING ·Phase: PHASE2
-
Apatinib Combine With Platinum-Based Doublet Chemotherapy for First-line Treatment of Advanced NSCLC
NCT03201146 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Efficacy and Safety of Glumetinib Combined With Osimertinib Mesylate Versus Platinum-based Doublet Chemotherapy in Non-Small Cell Lung Cancer Patients After Resistance to EGFR-TKIs
NCT06829459 ·Status: RECRUITING ·Phase: PHASE3
-
Study of High Efficient Killing Cell Therapy for Advanced NSCLC
NCT03193567 ·Status: RECRUITING ·Phase: PHASE1
-
PD-1 Combined With Dasatinib for as Third-line Treatment for ARID1A Mutation Advanced NSCLC
NCT04284202 ·Status: UNKNOWN ·Phase: PHASE2
-
Almonertinib With Chemotherapy in mEGFR NSCLC
NCT04646824 ·Status: UNKNOWN ·Phase: PHASE2
-
Assessment of Anti-tumor and Safety in Glumetinib in Patients With c-MET-positive Non-Small Cell Lung Cancer
NCT04270591 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Anlotinib Combined With Pemetrexed And Carboplatin as First-line Treatment in Advanced Nonsquamous NSCLC
NCT03790228 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of Icotinib With Chemotherapy as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
NCT05104788 ·Status: RECRUITING ·Phase: PHASE2
-
Gefitinib With or Without Chemotherapy in Brain Metastases From Non-small Cell Lung Cancer
NCT01951469 ·Status: UNKNOWN ·Phase: PHASE3
-
Efficacy of Targeted Therapy Combined Chemotherapy in Advanced EGFR Positive NSCLC Patients
NCT04552613 ·Status: COMPLETED ·Phase: NA
-
Efficacy of Osimertinib in Patients With Lung Cancer
NCT06174857 ·Status: RECRUITING
-
Study of Capmatinib in Chinese Adult Patients With Advanced Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation
NCT04677595 ·Status: COMPLETED ·Phase: PHASE2
-
Apatinib Combined With Vinorelbine for Non-driver Gene Mutation Non-small Cell Lung Cancer
NCT03652857 ·Status: COMPLETED ·Phase: PHASE2
-
An Exploratory Basket Study of Pyrotinib Maleate Tablets in HER2 Mutated or Amplified of Metastatic Solid Tumors
NCT05274191 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of AK119 and AK112 With or Without Chemotherapy for NSCLC Patients
NCT05636267 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study Comparing AC0010 and Chemotherapy in Patients With Advanced NSCLC Who Have Progressed Following Prior EGFR TKI
NCT03058094 ·Status: WITHDRAWN ·Phase: PHASE3
-
A Study to Determine the Efficiency For Brain Metastasis NSCLC Patients Treated With Icotinib Alone or Combined With Radiation Therapy
NCT04058704 ·Status: UNKNOWN ·Phase: PHASE3
-
Intrathecal Pemetrexed Combined With High-dose Furmonertinib and Beva for EGFR-m NSCLC With Leptomeningeal Metastases
NCT06537297 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
XZP-5809-TT1 Tablets in Patients With T790M Mutation-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT04622072 ·Status: TERMINATED ·Phase: PHASE1
-
Genius Study Study to Compare Efficacy and Safety of Gefitinib/ Pemetrexed With Pemetrexed Alone as Maintenance Therapy in Patients With Stage IV EGFR Mutation Negative or T790M Single Mutation Who Respond to Pemetrexed/ Platinum as First-line Therapy
NCT01579630 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Influence of Prior Chemotherapy on Clinical Benefit With Erlotinib in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer With or Without EGFR Gene Mutation
NCT01204307 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Platinum-based Chemotherapy + Bevacizumab + Durvalumab, and Salvage SBRT for IV Non-Small Cell Lung Cancer Patients With EGFR Mutations After Failure of First Line Osimertinib: A Multicenter, Prospective, Phase II Clinical Study
NCT04517526 ·Status: UNKNOWN ·Phase: PHASE2