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The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)

NCT04291235 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 332

Last updated 2020-03-02

No results posted yet for this study

Summary

This trial in brain-injured patients will test which of the following will lead to better patient outcomes: (1) an airway management pathway consisting of daily assessments and removal of the breathing tube as soon as patients can breathe on their own and appear able to protect their airway; versus (2) the usual treatment patients would have received if they were not enrolled in this trial.

Conditions

  • Acute Brain Injury

Interventions

PROCEDURE

Airway Management Pathway

Patients in this group will receive several components that comprise airway management pathway: (1) daily spontaneous breathing trials (SBTs); (2) prompt extubation following successful extubation readiness criteria; (3) high-flow nasal oxygen for at least 24 hours following extubation.

PROCEDURE

Usual Care

Patients in this group will be treated according to usual care, which may include extubation or tracheostomy timed according to treating physicians' discretion.

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Sunnybrook Health Sciences Centre

    lead OTHER

Principal Investigators

  • Niall Ferguson, MD, MSc · Toronto General Hospital

  • Damon Scales, MD, PhD · Sunnybrook Health Sciences Centre

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-01
Primary Completion
2023-01-01
Completion
2023-01-01

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04291235 on ClinicalTrials.gov