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Overcoming Obstacles in Epigenetic Analysis of Human Twins

NCT04279704 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2020-10-28

No results posted yet for this study

Summary

Background Cardiovascular disease is the leading cause of death in the U.S., however scientists have failed to learn fully what are the causes of this disease. A promising lead in understanding the origins of cardiovascular disease may be in gene expression changes occurring in utero in response to environmental (non-genetic) factors. Such changes govern whether a gene is turned on or turned off during an individual's lifetime. Twin pregnancies and twin infants help researchers to have a better understanding of whether the gene expression changes are genetic or environmental in origin. Therefore, the purpose of this project is to examine which body tissues (such as hair, fingernails, urine or blood) are needed to accurately study how gene activity is affected by prenatal factors.

Conditions

  • Cardiovascular Risk Factor

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • Baylor College of Medicine

    lead OTHER

Principal Investigators

  • Alexis C Wood, PhD · Baylor College of Medicine

Eligibility

Min Age
1 Month
Max Age
6 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-09-30
Primary Completion
2020-03-31
Completion
2020-03-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04279704 on ClinicalTrials.gov