Speech, Linguistic and Acoustic Markers in Parkinson's Disease

Summary

The Investigators aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. The Investigators will administer speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls. The Investigators will also explore the associations between genetic factors and speech and cognitive status in Parkinson's disease.

Conditions

• Parkinson Disease
• Cognitive Impairment, Mild
• Speech

Interventions

DIAGNOSTIC_TEST

Cognitive Battery

Participants will be asked to complete a series of cognitive testing (testing of concentration, memory, and other thinking abilities).

BEHAVIORAL

Voice, Speech and Language Analysis

Participants will be asked to perform speaking and reading tasks, which will be recorded. Participants will be asked to complete a laptop-based test of language comprehension.

BEHAVIORAL

Questionnaires and Clinical Assessments

Participants with Parkinson's disease will complete an examination of their symptoms and questionnaires assessing disease symptoms, mood and activities of daily living. Healthy controls participants will be asked to complete questionnaires on mood.

GENETIC

DNA Analysis

Participants will have their blood drawn for DNA analysis.

Sponsors & Collaborators

• Boston University

  collaborator OTHER

• VA Puget Sound Health Care System

  collaborator FED

• National Institute on Deafness and Other Communication Disorders (NIDCD)

  collaborator NIH

• Massachusetts Institute of Technology/Lincoln Labs

  collaborator UNKNOWN

• University of Massachusetts, Worcester

  lead OTHER

Principal Investigators

• Kara Smith, MD · UMass Medical School

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-01-13

Primary Completion

2023-09-01

Completion

2025-02-28

Countries

• United States

Study Locations