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Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre

NCT04265144 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 500

Last updated 2025-09-04

No results posted yet for this study

Summary

Systemic sclerosis (SSc) is a rare form of connective tissue disease characterized by vascular involvement and the intensity of fibrosis. The lack of available treatment is largely due to the very fragmented understanding of the pathophysiology of SSc. However, one of the keys to conducting quality research on this disease remains the development of well-documented patient cohorts with reliable biological samples. The main objective of this cohort is to study the natural progression of SSc in a cohort of patients followed over 5 years.

Conditions

Interventions

BIOLOGICAL

Blood samples

62 ml whole blood for Peripheral blood mononuclear cell (PBMC) and monocytes isolation

OTHER

Biopsy

Skin biopsies only for volunteers among patients

OTHER

Bronchoalveolar samples

50 ml of bronchoalveolar samples if pulmonary flare requires this type of exploration only for volunteers among patients

OTHER

Biopsy

Digestives biopsies if requires this type of exploration in the standard of care only for volunteers among patients

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Principal Investigators

  • Marie-Elise TRUCHETET, MD, PhD · University Hospital, Bordeaux

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-08
Primary Completion
2034-06-30
Completion
2034-06-30

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04265144 on ClinicalTrials.gov