Systemic sclerosis is a rare autoimmune connective tissue disease characterized by skin thickening, fibrosis, and involvement of internal organs and vasculature. Clinical manifestations vary from limited cutaneous disease to diffuse multisystem involvement.
AbbVie reported positive Phase 3 data for Skyrizi's subcutaneous Crohn's disease treatment and is advancing lutikizumab and Rinvoq in hidradenitis suppurativa, with multiple readouts expected throughout 2026 as the company pursues combination therapy strategies.
A 24-year-old woman with refractory lupus achieved two successful pregnancies following dual-target CAR-T cell therapy, while bispecific T cell engagers showed efficacy in treatment-refractory antisynthetase syndrome and systemic sclerosis patients.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07782450 |
A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT07737470 |
Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research |
NOT_YET_RECRUITING | |
| NCT07717060 |
Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic Sclerosis |
NOT_YET_RECRUITING | NA |
| NCT07697274 |
Hyaluronidase for Sclerodactyly in Systemic Sclerosis Trial |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07676266 |
A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy |
NOT_YET_RECRUITING | PHASE1 |
| NCT07649265 |
A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body |
NOT_YET_RECRUITING | PHASE1 |
| NCT07596680 |
CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07558850 |
Exploratory Clinical Study of Anti-CD19/BCMA Universal CAR-T Cell Injection for the Treatment of Refractory Autoimmune Diseases |
RECRUITING | NA |
| NCT07515638 |
Immun4Cure Cohort of Autoimmune Diseases |
RECRUITING | |
| NCT07497087 |
A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis |
RECRUITING | PHASE3 |
