Treatment and Prevention of Progression of Interstitial Lung Disease in Systemic Sclerosis

Summary

Systemic sclerosis (SSc) is an orphan, multiorgan disease affecting the connective tissue of the skin and all internal organs. Interstitial lung disease is a frequent morbidity and mortality-driving manifestation in systemic sclerosis.

This observational trial (OT) is part of the collaborative project "DeSScipher", one out of five OTs to decipher the optimal management of systemic sclerosis. Aim of this observational try is to identify:

* The state of clinical practice in Europe for prevention and treatment of interstitial lung disease and its impact on lung function and disease progression
* The potential predictors and confounders for response to therapy

Conditions

• Systemic Sclerosis
• Interstitial Lung Diseases

Sponsors & Collaborators

• European Union

  collaborator OTHER

• University of Giessen

  collaborator OTHER

• University of Zurich

  collaborator OTHER

• University of Paris 5 - Rene Descartes

  collaborator OTHER

• University of Florence

  collaborator OTHER

• University of Campania Luigi Vanvitelli

  collaborator OTHER

• University of Basel

  collaborator OTHER

• University College, London

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• University of Pecs

  collaborator OTHER

• University of Leeds

  collaborator OTHER

• Schoen Klinik Hamburg Eilbek

  collaborator OTHER

• Gabriela Riemekasten

  lead OTHER

Principal Investigators

• Gabriela Riemekasten, Prof. · Charité Universitätsmedizin Berlin, Charité Centrum 12 für Innere Medizin und Dermatologie, Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie

• Christopher Denton, Prof. · Royal Free Hospital, University College London London

• Ulf Müller-Ladner, Prof. · Justus-Liebig-University Gießen, Kerckhoff Clinic, Departement of Rheumatology and Clinical Immunology

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-05-31

Primary Completion

2016-06-30

Completion

2016-06-30

Countries

• France
• Germany
• Hungary
• Italy
• Switzerland
• United Kingdom

Study Locations