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Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury

NCT04257240 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 230

Last updated 2020-02-05

No results posted yet for this study

Summary

Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.

Conditions

  • Ischemic Reperfusion Injury
  • Liver Injury
  • Cancer Recurrence
  • Malignancy
  • Liver Cancer

Interventions

PROCEDURE

selective hepatic vascular exclusion

major hepatectomy with vascular control of blood inflow and outflow of the whole liver

PROCEDURE

semielective hepatic vascular exclusion

major liver resection by selectively clamping the portal and hepatic vessels only of the lobe harboring the tumor

Sponsors & Collaborators

  • Aretaieion University Hospital

    lead OTHER

Principal Investigators

  • Kassiani Theodoraki, PhD · Aretaieion University Hospital

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2000-01-01
Primary Completion
2012-12-31
Completion
2012-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04257240 on ClinicalTrials.gov