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Identification of Image Phenotypes to Predict Recurrence After Resection of Hepatocellular Carcinoma

NCT05235490 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2022-02-11

No results posted yet for this study

Summary

Tumor recurrence, which occurs in 70% of patients with HCC within 5 years after hepatic resection, is a major cause of post-resection-death. This recurrence can be true recurrence (intrahepatic metastases), which occurs sooner than 2 years later, or it can be due to the development of de-novo tumors at least 2 years later. Despite this high rate of tumor recurrence, no anti-recurrence adjuvant therapies are currently recommended.

Imaging phenomics is the systematic, large scale extraction of imaging features for the characterization and classification of disease phenotypes. Combining imaging and tissue phenomics could be a solution to predict HCC recurrence. With the emergence of molecular therapies and immunotherapies, identifying patients with HCC at high risk of post-resection recurrence would help determine additional therapeutic and management strategies in clinical practice.

Conditions

  • CT Scans Prior to Surgery With a Least 2 Years of Follow-up

Interventions

OTHER

Non intervention

Data study with inclusion of patients and retrospective clinical data collection, combining : * Proofreading by radiologist of the CT scan performed (within 2 months prior to surgical intervention) * Proofreading by iBiopsy® of the CT scan performed (within 2 months prior to surgical intervention) * Proofreading of tumor sample slides by pathologists * Patients follow-up (imaging, clinical) * Recurrence-free survival

Sponsors & Collaborators

  • Median Technologies

    collaborator INDUSTRY

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Maïté LEWIN, Professor · Paul Brousse Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-28
Primary Completion
2022-01-28
Completion
2022-02-09

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05235490 on ClinicalTrials.gov