MedTrace Logo

Bioaerosol Sampling in Suspected Pulmonary Tuberculosis

NCT04241809 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2023-03-27

No results posted yet for this study

Summary

Tuberculosis (TB) is transmitted in bioaerosols containing Mycobacterium tuberculosis (Mtb). Mtb-containing bioaerosols are likely related to host infectiousness and central to ongoing TB transmission. No routine diagnostic assay exists to measure Mtb in bioaerosols. Furthermore, published studies of Mtb in bioaerosol samples, have been limited to individuals with sputum-positive pulmonary TB. Currently TB diagnosis is based on clinical symptoms and sputum laboratory findings. However, approximately half of all patients commencing TB treatment are sputum negative resulting in a high proportion of presumptive treatments. We therefore propose to use a sensitive sampling protocol to investigate the prevalence of Mtb-containing bioaerosols in both sputum-positive and sputum-negative TB suspects.

Conditions

  • Pulmonary Tuberculosis Confirmation by Sputum Microscopy With or Without Culture

Interventions

DIAGNOSTIC_TEST

Bioaerosol Sampling

Cyclone collection of exhaled bioaerosol

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • University of Cape Town

    collaborator OTHER

  • Zeteo Tech Incorporated

    collaborator UNKNOWN

  • Desmond Tutu HIV Foundation

    lead OTHER

Eligibility

Min Age
13 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-05-15
Primary Completion
2022-05-27
Completion
2022-05-27

Countries

  • South Africa

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04241809 on ClinicalTrials.gov