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Inflammation and Cardiovascular Health in Women

NCT04224181 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2024-02-20

No results posted yet for this study

Summary

Systemic immune activation and inflammation are believed to play a significant role in the development and clinical course of myocardial infarction (MI). Among women with HIV (WHIV), heightened systemic immune activation and inflammation persist, even when HIV infection is well-treated with contemporary antiretroviral therapeutic regimens. Moreover, WHIV in high-resource regions face a three-fold increased risk of myocardial infarction as compared with matched non-HIV-infected women. The goals of this study are to better understand ways in which HIV infection-incited systemic immune activation and inflammation augment MI risk among women.

Conditions

Interventions

RADIATION

Cardiac PET

A scan examining blood flow to the heart

RADIATION

99mTc-tilmanocept SPECT/CT

A scan to look at inflammation in the arteries

RADIATION

Contrast Enhanced Coronary and Aortic Computed Tomography Angiography

A scan of the heart and surrounding blood vessels

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Markella V. Zanni, MD · Massachusetts General Hospital

Eligibility

Min Age
40 Years
Max Age
79 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-02-03
Primary Completion
2023-11-09
Completion
2023-11-09

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04224181 on ClinicalTrials.gov