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Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects

NCT02874703 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2019-10-15

No results posted yet for this study

Summary

In this study, investigators plan to test two potential mechanisms contributing to diastolic dysfunction among asymptomatic persons with HIV who are on cART. The first proposed mechanism is that heightened systemic immune activation/inflammation in HIV contributes to myocardial inflammation, which in turn promotes myocardial fibrosis. The second mechanism is that ectopic fat deposition (increased visceral adiposity) in HIV relates to increased intramyocardial lipid content, which in turn contributes to diastolic dysfunction. Both HIV positive and HIV-negative participants will undergo cardiac MRI/ MRS imaging studies for evaluation of myocardial fibrosis, myocardial inflammation, and intramyocardial lipid content. Traditional markers of CVD risk, inflammatory markers/immune, hormonal markers, and markers of myocardial stretch/injury will be assessed in relation to cardiac MRI/MRS outcomes. Additionally, a small subset of participants with HIV will undergo longitudinal evaluations to assess effects of a clinically prescribed hormonal therapy on myocardial structure and function.

Conditions

  • HIV
  • Diastolic Dysfunction
  • Myocardial Fibrosis

Interventions

OTHER

Cardiac MRI/MRS

Sponsors & Collaborators

  • President and Fellows of Harvard College

    collaborator UNKNOWN

  • Nutrition Obesity Research Center at Harvard

    collaborator UNKNOWN

  • Massachusetts General Hospital

    lead OTHER

Eligibility

Min Age
40 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-08-31
Primary Completion
2019-08-31
Completion
2019-08-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02874703 on ClinicalTrials.gov